The precursors of lysosomal hydrolases are covalently modified by the addition of mannose 6-phosphate
(M6P) groups in the cis Golgi network. They then become segregated from all other types of proteins in the
trans Golgi network because adaptins in the clathrin coat bind the M6P receptors, which, in turn, bind the
modified lysosomal hydrolases. The clathrin-coated vesicles produced bud off from the trans Golgi network
and fuse with late endosomes. At the low pH of the late endosome, the hydrolases dissociate from the M6P
receptors, and the empty receptors are recycled to the Golgi apparatus for further rounds of transport. It is
not known which type of coat mediates vesicle budding in the M6P receptor recycling pathway. In the late
endosomes, the phosphate is removed from the mannose sugars attached to the hydrolases, further ensuring
that the hydrolases do not return to the Golgi apparatus with the receptor.
The Clipboard Game!!! Press Ctrl-V!!!
Moderator:Æron
What would happen if i go?
Just leave without any reason why
Would someone wonder why?
Would someone miss me?
What would happen if i couldn't take it?
Just break without any signs of proud
Would someone pick it up? Or help me out
Cause life ain't easy for me
Ain't easy, alone
This is my path
It's lonely
What would happen if i change
Just wake up one day not quite the same
Would someone wonder why
Would someone know
How i was before
Nothing like me
No, i don't know when , i am not the one
I was
Who i was
Cause life ain't easy for me
Ain't easy, alone
This is my path
It's lonely
Just leave without any reason why
Would someone wonder why?
Would someone miss me?
What would happen if i couldn't take it?
Just break without any signs of proud
Would someone pick it up? Or help me out
Cause life ain't easy for me
Ain't easy, alone
This is my path
It's lonely
What would happen if i change
Just wake up one day not quite the same
Would someone wonder why
Would someone know
How i was before
Nothing like me
No, i don't know when , i am not the one
I was
Who i was
Cause life ain't easy for me
Ain't easy, alone
This is my path
It's lonely
Scurry, scurry, Scurryous! You might just be the murriest. You certainly are the furriest! Hurry! Scurry! Scurryous!
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Dr. Sticks
- Posts:2319
- Joined:Mon Nov 17, 2008 12:48 pm
- Location:Alabama
- Contact:
http://www.spingain.com/?ref=146518
Well put doog. You never posted anything offensive whatsoever
we know she'll be back, like a good bitch should.
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RocketGirl
- Posts:913
- Joined:Mon Jan 05, 2009 6:06 am
- Location:At the bottom of the sky
- Contact:
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RocketGirl
- Posts:913
- Joined:Mon Jan 05, 2009 6:06 am
- Location:At the bottom of the sky
- Contact:
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lastwyvern
- Posts:707
- Joined:Thu Sep 04, 2008 1:37 am
- Location:Making out. With a cactus.
06
Anami and Anami are sitting around Anami says "GRR I AM ANGSTY LET'S EXPRESS ANGST" and so Anami says "ONE OF THE MODS ON DC IS A DICK I POSTED A PICTURE THAT WASN'T REALLY THAT INAPPROPRIATE AND THREE MODS SAW IT AND DID NOTHING THEN A FOURTH ONE SAW IT AND DELETED IT" and Anami says "OMG I HATE MODS >:("
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RocketGirl
- Posts:913
- Joined:Mon Jan 05, 2009 6:06 am
- Location:At the bottom of the sky
- Contact:
Stephen versus Stephanie. Can't you see they're just yin and yang? Matter and antimatter? It's staring us right in the face; they're the light and dark versions of each other, doomed to be locked in an eternal struggle that will consume us all!
Introducing new Dark Side RocketGirl™: Quicker, Easier, More Seductive!
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